Advance Blog

July 19, 2022

Nutraceuticals and Mindfulness: Combating Cognitive Impairment from Poor Mental Health 

Anthony Jude Tan, Founder and Visionary, AJT Wellity
For Vitafoods Insight’s Asia Virtual Expo 2022

Cognition is defined as the mental process of knowing, and to that end the ability to perceive, reason, and make judgments. Some of us are predisposed to conditions that make us more susceptible to cognitive decline, such as gender, age, and genetics that make one prone to mental illness. Here, we explore the factors we can control, namely the number of unhealthy mental days, and cutting out bad lifestyle habits. 

Mental health refers to the psychological and emotional ability to make decisions, contributing to overall behavioural and social wellbeing. We are fortunate to be living in a time where we are slowly dismantling the stigma surrounding mental illness and bad mental health. While there is still much to be done in that department, we’ve certainly made progress in demanding for more recognition of mental wellbeing, particularly in the workplace. The link between mental health and physical health has been brought to the fore in recent years through a greater acknowledgement of the importance of mental wellbeing in general, especially during these unprecedented times. You can watch AJT Wellity’s presentation at the Vitafoods Expo 2022 on this topic by registering for free here. I have also done a piece on nutraceuticals and its effects on immunity. The emotional impact of mental health is also well understood, but its impact on cognitive functioning hasn’t been met with the same recognition. 

Anxiety disorder is one the most common mental disorders affecting the global population. Anxiety is part of the fight or flight response, which is beneficial in alerting us from harm. Left unmanaged, however, this has deleterious effects on cognitive functioning. Prolonged stress and anxiety cause a shrink in the hippocampus over time, and impairs the functioning of the prefrontal cortex. This could lead to an increased chance of developing depression and dementia down the line. 

It is also linked to memory loss: repeated exposure to anxiety and stress releases excessive levels of cortisol, impairing memory retrieval. Research also shows that anxiety is an early predictor of impaired cognitive function in the future. A study done by UC Irvine demonstrated how even short-term stress lasting a few hours can impair the process behind collecting and retaining information. 

Common Physical Behaviours of Bad Mental Health and Its Toll on Cognition

Lack of Sleep and Insomnia

Chronic sleep deprivation caused by stress and anxiety leads to overworked neurons, which consequently lead to impaired cognitive function. In a study done by Michigan State university that involves a single night of sleep deprivation, participants who were deprived of sleep had a 30% error rate on a cognitive test done on them, a 15% increase from the previous evening. The number of lapses in attention also tripled. By contrast, the rested group performed consistently.  Over a longer term, sleep deprivation can lead to cognitive decline and dementia.

Stress Eating

Calorie intake and dietary composition have a significant and lasting impact on cognitive functioning and emotion. Some of us may have heard of the term “comfort food”. Numerous studies have demonstrated that physical or emotional distress leads to an increased consumption of high fat and sugar foods. Once consumed, the feedback effect that results is one that reduces stress-related emotions. Studies have shown that low glycemic index foods correlate with improved attention, memory, and functional capacity, while foods high in sugars cause concentration difficulties and low attention span. Amino acids and catecholamines are necessary for the synthesis of neurotransmitters- decreased levels of serotonin are associated with difficulties in memorizing, learning, and reasoning. 

Alcohol Abuse 

Some people develop an unhealthy relationship with alcohol to quell chronic emotional distress, to self-medicate. Studies have shown that those with specific mental health disorders, such as generalised anxiety disorder, panic disorder, agoraphobia, and social anxiety disorder are more likely to abuse alcohol consumption.  Alcohol depresses the Central Nervous System, offering temporary relief from anxiety. However, unbridled consumption, over time, is detrimental to memory, lead to cognitive decline and increased chances of developing dementia. The good news is that abstinence from overconsumption of alcohol can repair cognitive impairment. 

It should also be reassuring to know that beyond that, cognitive impairment caused by poor  mental health is somewhat reversible due to our brain’s neuroplasticity. 

How Nutraceuticals and Supplements Improve Cognition

A bad diet negatively impacts cognitive functioning, so it stands to reason that a healthy diet and nutraceuticals have been proven effective in improving it. The research area related to food supplement and brain physiopathology is attracting a constantly growing interest. AJT Wellity Asia has formed a partnership with non-profit scientific organisation ReGenera R&D International for Aging Intervention and Asia affiliates, which have done extensive research on how nutraceuticals, supplements, and vitamins are instrumental in maintaining cognitive function. Founder, Prof.  Francesco Marotta, MD,  PhD (JP) MACG (USA) illustrates that on an experimental basis it has been shown that docosahexaenoic acid, Eicosopentanoic acid, uridine monophosphate, choline, iodine, zinc, and vitamin B12 proved to be effective in a mouse model of perinatal hypoxia-ischemia. In a clinical setting, there is wide evidence that n-3 polyunsaturated fatty acids (n-3 PUFAs) are highly correlated to cognition and depression. Very recent data have also pointed out potential interactions among diet, gastrointestinal microbiota and epigenetic alterations on brain methylation and on cytosine methylation dynamics in the adult brain. For instance, non-digestible oligosaccharides seem to act as beneficial prebiotics while some probiotics and “bioengineered” probiotics have shown a significant pro-longevity and neural protection in experimental models of ageing or neurodegeneration. 


Many people are struggling with the emotional long-haul of the pandemic in some way or another whether it is anxiety, depression, stress, burnout, or languishing. More importantly, what can we do to manage our mental health sustainably – after all, prevention from the root cause is far more effective than tackling each issue as they come. 

Following from the properties of neuroplasticity, engaging in mindfulness practice fundamentally changes our brain structure. A meta-analysis of 47 studies have shown that anxiety and depression can be treated through meditation programs such as Mindfulness-based Cognitive Therapy and Stress Reduction (MBCT and MBSR, respectively). The reduction of mental stress post mindfulness practice is comparable to the effectiveness of an antidepressant. An equally important finding is that in a randomised trial of the Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse published by Jama Psychiatry, when compared to antidepressants and other forms of treatment, relapse rates are reduced by up to 60 weeks. This result is uniform across all genders, age, or education. 

In fact, just 8 weeks of mindfulness meditation (MBSR) has been shown to reduce stress, depression, and emotional exhaustion caused by burnout, a key problem facing society in the 2020s. Our mindfulness meditation coaches at our iRETREAT wellness retreats advise starting out with short 5 to 10 minute daily mindfulness meditation sessions, and gradually increasing the duration – the deeper one gets into his or her mindfulness practice. However what is emphasised during these sessions is not the duration of the meditation, but instead the consistency of practising every day in order to clear the mind, and achieve better mental wellbeing.  

Mindfulness meditation is also associated with improved cognition. Meta-awareness and cognitive flexibility resulting from MBCT actually helps with acknowledging negative thought patterns and developing a new perspective to respond to these experiences. 

Mindfulness practices additionally prevent the aforementioned common physical problems and vices stemming from bad mental health: a meta-analysis of 34 randomised controlled trials on mindfulness-based treatment of addiction found that mindfulness significantly reduced cravings, increased nonreactivity to emotional distress, and heightened executive functioning. Mindfulness meditation also helps with chronic insomnia: in a study on 54 adults with chronic insomnia, a specifically tailored mindfulness program, Mindfulness-Based Therapy for Insomnia (MBTI), has shown significant reduction in sleep disturbances. 

Ultimately, developing positive habits as opposed to chasing vague concepts to ensure sustainability and consistency. This is a path I personally walked down, after having struggled with my own mental health as an entrepreneur and business owner when Covid-19 hit globally in 2020. I had found solace in meditation and took it a step further by living the simple life as a monk for a month last year to improve my own mental health. My daily mindfulness meditation practice is coupled with regular exercise, a balanced diet, and vitamin supplements which aid my cognitive and immune health. 


Anthony Jude Tan is Founder and Visionary at AJT Wellity Asia, a Medical Wellness Consultancy & Management for the Healthcare, Wellness and Hospitality Industries.

ReGenera R&D International for Aging Intervention is a R&D and scientific clinical research non-profit organisation for prevention and anti-aging.

For media enquiries, please contact:

Numtarn Imcharoenkul, Business Communications Executive

Phone: +66 84 020 0433 Email: [email protected]

Alexsondra Nicole Tan, Business and Marketing Manager

Phone: +66 95 890 0695 Email: [email protected]


Anthony Jude Tan
Founder and Managing Director of AJT Wellity Asia, is a well-respected professional with over 30 years of diverse experience in the hospitality and service industry. He has most recently spent the last 16 years in top level management within the wellness and healthcare industry.

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